PacBio, a leading developer of high-quality, highly accurate sequencing solutions, announced the launch of its Multiplexed Arrays Sequencing (MAS-Seq) kit in partnership with the Broad Institute of MIT and Harvard and 10x Genomics, Inc. The kit is a first-of-its-kind kitted solution leveraging 10x Genomics’ Single Cell Gene Expression technology to enable cost-effective long-read single-cell RNA sequencing for a more complete interrogation of the transcriptome. Insights generated from single-cell RNA sequencing experiments can power new disease discoveries and the identification of therapeutic targets across many categories.
“We’re thrilled to collaborate with these innovative organizations and bring new capabilities to our customers, enabling them to unlock new discoveries in their research,” said Christian Henry, President and Chief Executive Officer of PacBio. “With this first-of-its-kind kit, PacBio aims to empower customers’ single-cell research in a way that has not been possible before. The availability of MAS-Seq is a significant milestone for PacBio.”
MAS-Seq will help single-cell researchers better identify and characterize novel isoforms, novel driver mutations, and cancer fusion genes, which are particularly relevant in the fields of cancer research and neurodegenerative diseases.
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“Understanding cell heterogeneity at the isoform level is critical for basic and disease research,” said Jeff Eidel, Chief Commercial Officer at PacBio. “Our customers understand the need for HiFi sequencing to obtain full-length isoforms at single-cell resolution with accuracy. With the MAS-Seq technology, we aim to bring the throughput increase that enables customers to use HiFi for single-cell RNA sequencing in a cost-effective manner.”
Together with the kit, PacBio will also release new SMRTLink software that supports single-cell transcriptome analysis, helping researchers easily glean insights from their data.
“The single cell revolution has already led to groundbreaking discoveries in biomedical research and has transformed our understanding of disease and development, yet there are so many more research questions and applications waiting to benefit from the power of single cell analysis,” said Edwin Hauw, Vice President of Marketing for 10x Genomics. “We believe the ability to characterize single cells at the transcript isoform-level will fuel discoveries of new biomarkers that are important in both disease research and cellular function, helping to unlock new biological insights and open up new application areas. The combination of the MAS-Seq kit with our industry-leading Chromium assays is yet another way 10x Genomics is working to build and deliver the most comprehensive single cell portfolio for researchers worldwide.”