Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”) reached an agreement with BeiGene (Beijing) Co., Ltd. for licensing Biocytogen’s fully human antibody RenMab/RenLite mice platforms to develop fully human monoclonal antibodies, bispecific antibodies and other types of antibody drugs.
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RenMab™ and RenLite™ mice, which have proprietary intellectual property rights, were developed by Biocytogen over the course of 5 years using size-unlimited, precise chromosome engineering technology. In RenMab™ mice, the complete murine variable regions of the heavy and kappa light chains were replaced by full human heavy and kappa light chain V(D)J loci in situ; In RenLite™ mice, the variable regions of the murine heavy chain were completely replaced as in RenMab™ mice, and the whole murine variable regions of the κ light chain were replaced with a single human κ light chain VJ locus in situ. RenMab™/RenLite™ mice can generate fully human antibody candidates with high affinity, specificity, and diversity for downstream antibody drug screening. In addition, common light chain antibodies generated by RenLite™ mice can greatly improve the efficiency of downstream assembly of complex drug molecules such as bispecific antibodies and bispecific antibody-drug conjugates (bsADCs).
BeiGene is a global, science-driven biotechnology company focused on developing innovative and affordable medicines to improve treatment outcomes and access for patients worldwide. BeiGene currently has three approved medicines discovered and developed internally: BTK inhibitor BRUKINSA in the United States, China, the EU and Great Britain, Canada, Australia and additional international markets; and the non-FC-gamma receptor binding anti-PD-1 antibody tislelizumab as well as the PARP inhibitor pamiparib in China. BeiGene has established a number of internal technology platforms, including small molecule drug development platform, proteolysis targeting chimera (CDAC) technology platform and bispecific (multispecific) antibody discovery platform, single B-cell antibody screening platform and antibody-drug conjugate (ADC) development platform.
Dr. Yuelei Shen, Founder and CEO of Biocytogen, said, “As one of the leading fully human antibody discovery platforms, Biocytogen’s RenMab™/RenLite™ mice will provide strong support in drug development for challenging targets. Meanwhile, RenLite™ mice can generate bispecific antibodies with simple monoclonal antibody structures, reducing the difficulty of subsequent drug conjugation and opening up more possibilities for innovative drug development.”