Alector, a late-stage clinical biotechnology company focused on developing therapies to counteract the devastating progression of neurodegeneration, announced that Gary Romano, M.D., Ph.D., has made the decision to step down from his role as Chief Medical Officer. Dr. Romano will continue to contribute to the company as an advisor following his transition. Giacomo Salvadore, M.D., has been appointed Chief Medical Officer effective April 25, 2025. Dr. Salvadore is an established industry executive physician and leader with more than 15 years of experience leading neurology-focused clinical development functions. He joined Alector in 2023 as Senior Vice President of Clinical Development and has a deep knowledge and understanding of the company’s pipeline and strategic priorities.
“Dr. Romano has played a pivotal role in shaping our clinical pipeline, driving progress across our programs, and helping position Alector for long-term success. His leadership and strategic vision have been instrumental in advancing our development efforts, and we are grateful for his dedication and impact,” said Arnon Rosenthal, Ph.D., Chief Executive Officer. “As we continue advancing toward key transformative milestones, we are pleased to appoint Dr. Salvadore as our new Chief Medical Officer. Giacomo’s extensive leadership and expertise in neurology and clinical development, combined with his strong knowledge of our programs, make him exceptionally well-suited to lead our clinical efforts. Under his leadership, we remain well-positioned to execute our strategy and advance first- or best-in-class therapies for patients with neurodegenerative diseases.”
Also Read: Genomize and Genomenon Partner to Empower Researchers and Clinicians with Comprehensive Genomic Insights
Alector currently has two late-stage clinical candidates and five research and preclinical programs, selectively supported by its proprietary blood-brain barrier technology platform, Alector Brain Carrier (ABC). The company remains on track to report topline data from the pivotal INFRONT-3 Phase 3 trial of latozinemab in frontotemporal dementia with a granulin gene mutation (FTD-GRN) in Q4 2025 and to complete enrollment in the PROGRESS-AD Phase 2 trial of AL101 in early Alzheimer’s disease by mid-2025. Additionally, Alector plans to advance multiple early-stage programs supported by ABC into IND-enabling studies later this year, with first-in-human trials expected in 2026.
“It has been a privilege to work alongside the talented team at Alector to advance a pipeline of therapies designed to address the urgent needs of patients with neurodegenerative diseases,” said Gary Romano, M.D., Ph.D., Chief Medical Officer. “I am confident that under Dr. Salvadore’s leadership, Alector’s clinical and preclinical programs will continue advancing toward meaningful potential breakthroughs. I look forward to supporting the transition and the company’s continued success.”
SOURCE: GlobeNewswire