Bruker Corporation announced the launch of the Beacon Discovery™ Optofluidic System at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2025. This new Beacon benchtop system offers an accessible entry point into live single-cell functional analysis.
Building on Bruker’s proprietary Opto-Electrical Positioning (OEP) technology and scalable OptoSelect™ microfluidic chips, Beacon Discovery complements the floor-standing premium Beacon® platforms. All Beacon systems precisely isolate, control, and analyze single cells within Nanopens using machine learning-driven automation and OEP. Researchers can conduct multi-parameter and temporal functional analysis over days or weeks, combining live-cell imaging with sequential assays. Cells can then be recovered for downstream transcriptomic and genomic analysis, enabling a unique linkage between functional insights and sequencing data from the same cell.
While the existing higher-throughput Beacon platforms focus on fully automated therapeutic antibody discovery and cell line development for pharma and CROs, the new single-chip Beacon Discovery prioritizes ease of use and flexibility with an intuitive user interface and customizable workflows for translational research in academic and biotech laboratories.
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With a substantially reduced cost of ownership and lower running costs, Beacon Discovery lowers the barrier to entry for researchers and core labs exploring immuno-oncology, infectious diseases, autoimmune disorders, and immune profiling for regenerative medicine, antibody and T Cell Receptor (TCR) discovery, and cell therapy development.
One of the Beacon Discovery early-access users, Dr. Joseph Zenga, MD, Associate Professor and Division Chief at the Medical College of Wisconsin, highlighted the platform’s impact: “Having used the Beacon platform for years, we have seen firsthand how it transforms TCR discovery for cancer immunotherapy. Its automated workflows and novel multi-parameter temporal analysis allow precise characterization of tumor antigen-specific T cells, accelerating the identification of potent therapeutic candidates from patient tumor-infiltrating lymphocytes (TILs). With the new Beacon Discovery, this powerful technology is now within reach for many more individual and core labs in academia and industry.”
SOURCE: Businesswire