Nikon Instruments Inc., innovator of advanced microscope systems today announced the release of the AX R MP multiphoton confocal microscope, which can acquire high resolution, large field of view images, deep within living organisms at high speed.
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Development Background
Research fields such as neuroscience and immunology require the study of fast biological dynamics (e.g., cranial nerve signaling, blood flow) in large samples such as live tissues, and even whole animals with a microscope. These methods are continuously advancing and there is a demand for systems that support a broad range of experiments and enable lateral and axial observation of samples without changing their orientation. To meet such needs, Nikon manufactures high-speed multiphoton confocal microscopes that scan samples with an infrared ultrashort pulse laser*1, enabling observation of deep structures in three dimensions.
Now, Nikon has developed the AX R MP multiphoton confocal microscope, which enables high speed acquisition of high resolution, wide-field images. With an upright microscope configuration, a large space is provided under the objective to support a wide range of experiments and acquisition of images from various angles. The AX R MP efficiently acquires large amounts of data on ultrastructure in the deep regions of living organisms, supporting research into diverse biological phenomena.
*1 An infrared laser with pulse width from a few femtoseconds (1/10-15 seconds) to a few picoseconds (1/10-12 seconds). resulting in less photodamage to the sample.
Main Features
1. High speed scanning of high-resolution images with a large field of view to efficiently acquire large amounts of information
High resolution 2K x 2K (2048 × 2048 pixels) images with a large field of view (22 mm) can be acquired at high speed by combining the AX R MP with the dedicated AX-FNGP and AX-FNSP microscopes for multiphoton confocal systems, or the ECLIPSE Ti2-E inverted research microscope. Fast biological activities can be captured at high resolution right up to the periphery of the field of view using a resonant scanner. Large amounts of data can be acquired efficiently, supporting research of different biological phenomena.