Amicrobe, Inc. develops synthetic biologics with physical and antimicrobial properties, called Amicidins. the Company announced the selection of lead clinical formulation for Amicidin-α PFC (Prolonged Field Care), a key milestone in the development of a new product for military field care of injured warfighters.
Amicidin-α has a dual mode of action: physical/electrostatic barrier and microbicidal activity. Amicidin-α PFC is a dry powder formulation of Amicidin-α intended to prevent infection of traumatic wounds for prolonged periods (up to 72 hours). When applied to open wounds, it absorbs fluid, forming a gel capable of killing microbes and preventing further contamination.
Amicidin-α PFC is one of four investigational products designed to prevent and treat life-threatening infections in surgery and trauma – from operating rooms to field settings. Amicidin-α PFC is born from Amicrobe‘s Amicidin-α Surgical Gel program, using the same synthetic protein. Amicidins can be tailored to different product requirements across multiple industries through formulation and fabrication.
Amicidin-α PFC is supported by a $3.99M US Department of Defense award issued in August 2021 for development from formulation through a Phase 1/2a clinical trial. The award was granted by US Army Medical Research and Development Command’s (USAMRDC) Military Infectious Diseases Research Program (MIDRP) in collaboration with Medical Technology Enterprise Consortium (MTEC).
“Amicidin-α PFC is an innovative application of our Amicidin technology,” stated Dr. Michael Bevilacqua, CEO and CSO of Amicrobe. “We are excited for its potential to help injured warfighters prevent limb- and life-threatening infections in the field.”
Amicrobe engineers synthetic biologics called Amicidins. Drawing inspiration from nature, they possess physical properties and antimicrobial activity. Physical properties make them versatile; microbicidal activity brings protection against bacteria, fungi, and viruses. Like nature’s antimicrobials, Amicidins are designed to be biodegradable and safe for the environment. Amicrobe is headquartered in Carlsbad, California.