Veracyte, Inc. announced that new data show the use of the Prosigna Breast Cancer Assay altered treatment decisions for patients with early-stage breast cancer, including significantly reducing the use of chemotherapy among those with clinically high-risk disease. The findings are from EMIT, a prospective, multi-year, population-based study in Norway that is investigating the impact of molecular testing – specifically, the Prosigna test – on breast cancer care and outcomes. These initial data focused on treatment decisions and were shared in a poster (#103P) at ESMO Breast Cancer Congress 2023, taking place May 11-13 in Berlin.
“Our findings demonstrate the important role that gene expression testing, and in particular the Prosigna assay, can play in offering physicians better prognostic information to help guide next steps for their patients with breast cancer,” said Bjørn Naume, M.D., Professor at the Department of Oncology, Rikshospitalet Oslo University Hospital. “Specifically, Prosigna test results changed physicians’ treatment decisions in all patient clinical-risk groups with early breast cancer, regardless of whether they were low-, intermediate-, or high-risk, and reduced treatment discrepancies across hospitals.”
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The Prosigna assay analyzes the activity of the PAM50 gene signature, along with clinical-pathological features, to provide a hormone-receptor positive early breast cancer patient and her physician with a prognostic score indicating the probability of cancer recurrence during the next 10 years if treated with endocrine therapy alone. The Prosigna test is performed on the nCounter Analysis System and is available to laboratories in Europe and elsewhere to enable local testing for physicians and their patients.
“We are honored that the Prosigna test was selected to be part of EMIT, which we believe is among the most rigorous studies to evaluate the impact of gene expression testing on clinical decision-making and patient outcomes in breast cancer,” said Kelly Marcom, M.D., Veracyte’s medical director for Breast Cancer. “The findings presented at the ESMO Breast conference add to the growing body of evidence demonstrating the clinical utility of Veracyte’s Prosigna assay. We look forward to additional data that will come out of the EMIT trial as researchers continue to follow these patients over multiple years.”
SOURCE: Businesswire