Tuesday, November 5, 2024

Remidio’s Medios AI Shows Significant Promise in Last-Mile Screening for Referable Glaucoma

Glaucoma, one of the world’s leading causes of irreversible blindness, is expected to affect an estimated 120 million by 2040, globally. Treatment options for managing Referable Glaucoma – a stage where immediate treatment improves prognosis, exist, but a simple test to screen has been elusive. Today, the only way to detect is through complex investigations often requiring multiple devices handled by Glaucoma Specialists. Remidio Inc, alongside Aravind Eye Hospital (AEH), Pondicherry, and Narayana Nethralaya (NN), Bangalore, announced the results of a landmark clinical trial that can help revolutionize the detection of Referable Glaucoma.

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The integrated solution provides an instant report in contexts where there are no specialists. It consists of Remidio’s Fundus on Phone, an imaging device that captures images of the retina without pupil dilation, and Remidio‘s Medios Referable Glaucoma AI, an integrated offline AI algorithm that requires no internet for inferencing.

The AI looks beyond the cup-to-disc ratio and detects structural changes in the optic nerve head and surrounding retinal nerve fiber layer, critical regions typically assessed by glaucoma specialists during clinical examination with an expensive device called Optical Coherence Tomography.

This video shows how technology can screen for Referable Glaucoma in 15 seconds.

The diagnostic performance of the AI was validated in a first-ever prospective study conducted simultaneously at a tertiary eye care center, NN, and in last-mile access contexts, Vision Centers (VCs) of AEH.

Among the 237 study subjects at NN, the AI results were compared against the current standard of care, wherein Glaucoma specialists provided the final diagnosis following a comprehensive work-up. The algorithm demonstrated a high sensitivity of 93.5% (95% CI: 87.1-96.8%) to detect Referable Glaucoma with a specificity of 85.4% (95% CI: 78.3-90.4%). The recall for ‘no glaucoma’ was also high at 94.7% (95% CI: 87.1-97.9%) with a minimal overcall of normal subjects.

Dr. Rohit Shetty, Vice Chairman at NN, said, “Our clinical study at NN shows that AI can bring much-needed objectivity in glaucoma screening, especially in contexts where no specialists are present. We also see the power of AI to be used in applications as diverse as outreach screening to personalized care.”

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