Jiangsu Recbio Technology Co., Ltd. (Recbio), a China-based company focused on the development of innovative vaccines for major diseases, announced preclinical data of its subsidiary Wuhan Recogen Biotechnology Co., Ltd. (Recogen) on lyophilized mRNA vaccine. The lyophilized mRNA-LNP nanoparticle vaccine is delivered by an LNP delivery system and achieved stability at 4℃ and 25℃ based on a self-developed lyophilization technology. The vaccine can be stored and transported in conventional cold chain conditions, greatly improving the accessibility of mRNA vaccine. The results have been on the preprint server bioRxiv
Also Read: NeuroSense Therapeutics Extends ALS Biomarker Collaboration with Massachusetts General Hospital
According to this paper, Recogen developed the lyophilized mRNA-LNP nanoparticle vaccine targeting wild-type, Delta and Omicron SARS-CoV-2 variant, and the data showed that the lyophilized process did not affect the key physicochemical parameters, biological activity and immunogenicity of the vaccine. Notably, the Delta-specific mRNA vaccine can induce a high-level neutralization response in mice against both the wild-type and the current global pandemic strain Omicron. A virus challenge study of hACE2 transgenic mice shows the lyophilized mRNA-Delta vaccine is highly immunogenic and can fully protect the challenged mice from SARS-COV-2 infection and clear the virus.
Vaccines have become the world’s most cost-effective tool to respond to the COVID-19. As of now, more than 10 billion doses of COVID-19 vaccine have been administered globally. However, only 10% of people in low-income countries have received at least one dose of vaccine. Therefore, it is particularly important to develop an mRNA vaccine that can be transported in conventional cold-chain and be stored at 2℃~8℃, or at room temperature stably for broad application. Recogen successfully achieved the lyophilization of mRNA-LNP vaccine. This lyophilization platform could significantly improve the accessibility of mRNA vaccines or therapeutics, particularly in remote regions.
Recbio is an innovative vaccine company founded in 2012. With the vision of “Become the Leader of Innovative Vaccine in the Future,” Recbio takes “Protect Human Health with Best-in-Class Vaccines” as its mission. It has established three major cutting-edge technology platforms including novel adjuvants platform, protein engineering platform, and immunological evaluation platform. Recbio has a high-value vaccine portfolio consisting of HPV vaccine candidates, COVID-19 vaccine candidates, shingles vaccine candidates, influenza vaccine candidates, adult TB vaccine candidates, etc. The core management team has more than 20 years of experience in the development and commercialization of innovative vaccines.