Caris Life Sciences, the leading next-generation AI TechBio company and precision medicine pioneer that is actively developing and delivering innovative solutions to revolutionize healthcare and improve the human condition using molecular science and AI, announced that the company and collaborators within the Caris Precision Oncology Alliance (POA) will collectively present 11 studies across six solid tumor types at the 2024 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium, January 18-20, 2024 in San Francisco. The findings demonstrate the power of Caris’ comprehensive multi-modal database to enable novel insights into cancer that could have profound effects on a patient’s diagnosis, prognosis, care plan and response to treatment.
“We are proud to again present a wide array of precision oncology research at this year’s ASCO GI. The findings represent important observations in a variety of GI tumors, including potential new biomarkers for EGFRi efficacy in metastatic colorectal cancer, age stratification in cholangiocarcinoma, and a survey of immunogenic tumor neoantigens in colorectal, biliary, and pancreatic cancers,” said Chadi Nabhan, MD, MBA, FACP, Chairman of the Caris Precision Oncology Alliance.
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“We are confident that Caris’ powerful comprehensive molecular profiling, the matched clinical outcomes data, and the in-depth collaboration with our POA member institutions and investigators will lead to novel insights into cancer biology, new targeted therapies, and ultimately improved outcomes for all cancer patients.”
Posters from Caris include:
- Examining the molecular profiles of 5,587 cholangiocarcinomas (CCA) grouped by age of onset. Early-onset CCA has a significantly higher prevalence of FGFR2 fusion, a targetable mutation, as well as significant differences in immunotherapy-related markers, angiogenesis enrichment, and inflammatory response compared to average-onset CCA. Strikingly, patients with early-onset CCA experience better outcomes from immunotherapy even though immune-oncology-relevant markers like MSI and TMB favors average-onset CCA. These findings underscore the need for NGS testing and the potential for age-tailored therapeutic strategies:
SOURCE : PRNewswire