An innovative anticancer therapy that may complete chemotherapy with two doses of an anticancer drug in as short as 8 days is to enter a clinical trial for cancer patients. This chemotherapy is a patient-centered treatment that focuses on controlling toxicity of anticancer drug. This unprecedented chemotherapy is expected to help cancer patients receive outpatient treatments without suffering from side effects and live their normal lives at home and at work. Hyundai Bioscience announced on November 24th, 2022, that it is collaborating with an Australian cancer hospital for its global Phase 1 clinical trial on pancreatic cancer with Polytaxel, which was developed as so-called ‘pain-free’ anticancer drug, based on a novel inorganic polymer nanohybrid drug delivery platform technology. Polytaxel is loaded with docetaxel as its active pharmaceutical ingredient, which is known as one of the major chemotherapy drugs. Hyundai Bioscience will file its clinical plan to the Human Research Ethics Commission (HREC) of Australia as soon as its clinical design is confirmed with a local clinical trial institution.
Hyundai Bioscience held a press conference at Ewha Womans University on November 22nd, and unveiled its clinical trial design of Polytaxel along with NOAEL therapy, an innovative cancer therapy that may be administered without recovery break periods.
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“The clinical design of Polytaxel has a very unique dosing method compared to the existing standard treatment method of docetaxel,” said Park Kwang-Sik, president of Hyundai Bioscience‘s Bio Division. He said, “Based on the very low toxicity of Polytaxel, a completely new standard treatment to enable pain-free anticancer treatment has emerged.”
Hyundai Bioscience’s clinical trial design is basically to administer Polytaxel by 7-day interval to two separate groups of patients, twice for one cohort and three times for the other. For the two-dose group, it will take 8 days to complete administration, and 15 days for the three-dose group. Existing chemotherapy with docetaxel usually takes 3~6 months due to the fact that there needs to be a 3-week recovery period between doses.
It is remarkable that such dosing frequency of 7-day interval is the same as was applied to animal testing. In case of conventional chemotherapy, the patients must have a recovery period after drug injection due to severe side effects caused by the drug’s toxicity. That’s why the dosing interval from efficacy testing on animals is not equally adopted to human testing typically.
SOURCE: PR Newswire