Boundless Bio a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, announced that Robert (“Bob”) Doebele, M.D., Ph.D., has been appointed as Chief Medical Officer.
“We are excited to have Bob join Boundless at this pivotal time as we continue to advance the BBI-355 Phase 1/2 POTENTIATE trial and approach the selection of a development candidate for our Kinesin program,” said Zachary Hornby, President and Chief Executive Officer of Boundless Bio. “Bob has been a driving force behind precision oncology drug development throughout his career. His leadership in clinical development will be instrumental in advancing our ecDTx programs and, most importantly, in delivering novel treatment options to patients with oncogene amplified cancers.”
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Dr. Doebele was the co-founder of Rain Oncology, Inc., (acquired by Pathos AI), a precision oncology company, where he served as Chief Scientific and Medical Officer, directing the research and development of innovative therapies targeting oncogenic drivers in tumor-agnostic, biomarker-driven trials. Specifically, he led the clinical development plans for milademetan, a small molecule MDM2 inhibitor, Phase 2 planning for tarloxotinib, a hypoxia-activated pan-HER kinase inhibitor, and the development of a preclinical program focused on inducing synthetic lethality by inhibiting RAD52. Dr. Doebele previously led the research and clinical trials at the University of Colorado that launched the TRK inhibitor field by demonstrating that NTRK1/2/3 gene fusions represent a novel tumor agnostic target in cancer, a strategy that ultimately led to the approval of Vitrakvi (larotrectinib) and Rozlytrek (entrectinib). He also served as the director of the Thoracic Oncology Research Initiative at the University of Colorado Cancer Center and co-founded and co-directed the University of Colorado Molecular Tumor Board. Dr. Doebele received his M.D. and Ph.D. in Immunology from the University of Pennsylvania School of Medicine and an A.B. in Molecular Biology from Princeton University.
“I am thrilled to join Boundless Bio, a company focused on interrogating novel biology to develop treatments for patients with oncogene amplified cancers,” said Dr. Doebele. “In my career as a biotech executive, scientist, and clinician, I have witnessed the potential of precision oncology to deliver meaningful outcomes for patients. Despite these advancements, there are very few treatments that effectively treat patients with oncogene amplifications, and I look forward to joining Boundless’ mission to develop life-improving therapies for these patients.”
SOURCE: GlobeNewswire