ILC Dover, an Ingersoll Rand business and world leader in the innovative design and production for biopharmaceutical, pharmaceutical, and medical device markets, announced the capabilities of its EZJetFlo™technology, an advanced in-line powder induction and mixing system designed to help biopharmaceutical manufacturers simplify operations, improve consistency, and accelerate production.
Efficient powder dissolution remains a critical challenge in bioprocessing, where incomplete wetting, powder agglomeration, and long mixing times can impact batch quality, process efficiency, and scalability. EZJetFlo™ addresses these challenges through a Venturi-based design that rapidly entrains powders into a high-velocity liquid stream, enabling immediate wetting, dispersion, and dissolution in a fully closed, single-use process.
Recent testing documented in the whitepaper, Enhancing Biopharmaceutical Production Through Advanced Mixing: Boosting Performance with EZJetFlo™ Technology, demonstrated significant improvements in powder induction and mixing performance at a 900-liter scale.
The system operates in closed-loop recirculation mode, where accelerated liquid flow creates a vacuum of approximately –900 mbar, drawing powders directly into the process stream. This approach eliminates many of the limitations associated with traditional vessel-based mixing methods while providing consistent flow dynamics and streamlined operation.
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“Biopharmaceutical manufacturers are under constant pressure to improve productivity while maintaining product quality and process control,” said Paulo Bento, Director, Process Equipment & Field Applications. “EZJetFlo™ Technology delivers a scalable, efficient solution that helps customers reduce processing times, improve mixing consistency, and simplify operations in media and buffer preparation applications.”
Key performance findings include:
- Faster powder induction: Powder feed rates increased by approximately 25% when pump speed increased from 61% to 71%, demonstrating the direct relationship between process flow and Venturi-driven suction performance.
- Broad material compatibility: Stable, uninterrupted powder feeding was achieved across multiple materials, including sodium hydroxide (NaOH), glucose, and starch, without clogging or operational disruption.
- Rapid dissolution: For highly soluble materials such as NaOH, pH measurements shifted almost instantaneously from approximately pH 6 to pH 12, indicating fast dissolution and homogeneous distribution throughout the system.
- Exceptional mixing efficiency: More than 99.5% of solids dissolved within 2–3 minutes, with less than 0.5% retained particles observed on a 60-mesh screen, even when processing more challenging formulations.
Beyond performance improvements, EZJetFlo™ provides operational and sustainability benefits by reducing reliance on traditional tank agitation, lowering energy consumption, and minimizing maintenance requirements. The fully closed, single-use configuration also eliminates cleaning and cleaning validation requirements while significantly reducing cross-contamination risks supporting compliance with current GMP expectations and Annex 1 guidance.
SOURCE: PRNewswire