RCPE and InSilicoTrials agreed to an exclusive partnership to commercialize the XPS simulation software in May 2022. The two companies announce the launch of SimTabletCoater, an additional tool within the comprehensive XPS model portfolio. This tool is developed specifically for pharmaceutical applications. It makes it possible for companies to assess their process configurations in unprecedented detail and explore the decision space without time- and labor-intensive experiments.
Simulation-based process design, evaluation, and troubleshooting are indispensable in today’s industrial landscape. Various powder and solids handling industries, such as the pharmaceutical, food, and chemical industries, apply particle-based methods to simulate the flow behavior of particulate solids. Applications of those methods include geometry optimization, material processability issues, and process transfer or scale-up challenges.
Tablets are the most common dosage form because tablet production is economically efficient, dosing is comparably easy and accurate, and patient usage is simple, which leads to good compliance. However, designing the coating process can be a challenge. RCPE and InSilicoTrials joined forces to facilitate tablet coating simulations via an easy-to-use cloud interface. The GPU-based DEM solver XPS, developed by RCPE, is integrated into the InSilicoTrials cloud platform, adding a new tool to the comprehensive model portfolio: SimTabletCoater.
Finding the ideal operating conditions in the laboratory often requires multiple coating runs. Simulations with SimTabletCoater instead offer a comfortable way of surveying the parameter space and experimenting virtually with different coating setups. Parameters such as the tablet shape, the mass of tablets in the coater, the amount and composition of the spray applied over time, or the coater rotation speed can easily be varied to study their effect on the coating outcome. Superior to the laboratory setting, the virtual process exploration is not bottlenecked by the amount of available equipment and material.
SOURCE: PR Newswire